Adaptogenic plants are botanicals that help the body adapt to stress by modulating the hypothalamic-pituitary-adrenal (HPA) axis response. Ashwagandha, rhodiola, ginseng, eleuthero, and schisandra are among the best-documented adaptogens. Clinical studies show their ability to reduce cortisol, improve fatigue resistance, and enhance cognitive function under stress, with a generally favorable safety profile.